H5N1 Vaccine-Specific B Cell Responses in Ferrets Primed with Live Attenuated Seasonal Influenza Vaccines
Identifieur interne : 001096 ( Main/Exploration ); précédent : 001095; suivant : 001097H5N1 Vaccine-Specific B Cell Responses in Ferrets Primed with Live Attenuated Seasonal Influenza Vaccines
Auteurs : Xing Cheng [États-Unis] ; Michael Eisenbraun [États-Unis] ; Qi Xu [États-Unis] ; Helen Zhou [États-Unis] ; Deepali Kulkarni [États-Unis] ; Kanta Subbarao [États-Unis] ; George Kemble [États-Unis] ; Hong Jin [États-Unis]Source :
- PLoS ONE [ 1932-6203 ] ; 2009.
Abstract
Live attenuated influenza H5N1 vaccines have been produced and evaluated in mice and ferrets that were never exposed to influenza A virus infection (Suguitan et al., Plos Medicine, e360:1541, 2006). However, the preexisting influenza heterosubtypic immunity on live attenuated H5N1 vaccine induced immune response has not been evaluated.
Primary and recall B cell responses to live attenuated H5N1 vaccine viruses were examined using a sensitive antigen-specific B cell ELISpot assay to investigate the effect of preexisting heterosubtypic influenza immunity on the development of H5N1-specific B cell immune responses in ferrets. Live attenuated H5N1 A/Hong Kong/213/03 and A/Vietnam/1203/04 vaccine viruses induced measurable H5-specific IgM and IgG secreting B cells after intranasal vaccination. However, H5-specific IgG secreting cells were detected significantly earlier and at a greater frequency after H5N1 inoculation in ferrets previously primed with trivalent live attenuated influenza (H1N1, H3N2 and B) vaccine. Priming studies further revealed that the more rapid B cell responses to H5 resulted from cross-reactive B cell immunity to the hemagglutinin H1 protein. Moreover, vaccination with the H1N1 vaccine virus was able to induce protective responses capable of limiting replication of the H5N1 vaccine virus to a level comparable with prior vaccination with the H5N1 vaccine virus without affecting H5N1 vaccine virus induced antibody response.
The findings indicate that previous vaccination with seasonal influenza vaccine may accelerate onset of immunity by an H5N1
Url:
DOI: 10.1371/journal.pone.0004436
PubMed: 19209231
PubMed Central: 2635969
Affiliations:
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sortKey="Eisenbraun, Michael" sort="Eisenbraun, Michael" uniqKey="Eisenbraun M" first="Michael" last="Eisenbraun">Michael Eisenbraun</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>MedImmune, Mountain View, California, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>MedImmune, Mountain View, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Xu, Qi" sort="Xu, Qi" uniqKey="Xu Q" first="Qi" last="Xu">Qi Xu</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>MedImmune, Mountain View, California, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>MedImmune, Mountain View, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Zhou, Helen" sort="Zhou, Helen" uniqKey="Zhou H" first="Helen" last="Zhou">Helen Zhou</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>MedImmune, Mountain View, California, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>MedImmune, Mountain View, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Kulkarni, Deepali" sort="Kulkarni, Deepali" uniqKey="Kulkarni D" first="Deepali" last="Kulkarni">Deepali Kulkarni</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>MedImmune, Mountain View, California, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>MedImmune, Mountain View, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Insitutes of Health, Bethesda, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Insitutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Kemble, George" sort="Kemble, George" uniqKey="Kemble G" first="George" last="Kemble">George Kemble</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>MedImmune, Mountain View, California, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>MedImmune, Mountain View, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Jin, Hong" sort="Jin, Hong" uniqKey="Jin H" first="Hong" last="Jin">Hong Jin</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>MedImmune, Mountain View, California, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>MedImmune, Mountain View, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Live attenuated influenza H5N1 vaccines have been produced and evaluated in mice and ferrets that were never exposed to influenza A virus infection (Suguitan et al., Plos Medicine, e360:1541, 2006). However, the preexisting influenza heterosubtypic immunity on live attenuated H5N1 vaccine induced immune response has not been evaluated.</p></sec><sec><title>Methodology and Principal Findings</title><p>Primary and recall B cell responses to live attenuated H5N1 vaccine viruses were examined using a sensitive antigen-specific B cell ELISpot assay to investigate the effect of preexisting heterosubtypic influenza immunity on the development of H5N1-specific B cell immune responses in ferrets. Live attenuated H5N1 A/Hong Kong/213/03 and A/Vietnam/1203/04 vaccine viruses induced measurable H5-specific IgM and IgG secreting B cells after intranasal vaccination. However, H5-specific IgG secreting cells were detected significantly earlier and at a greater frequency after H5N1 inoculation in ferrets previously primed with trivalent live attenuated influenza (H1N1, H3N2 and B) vaccine. Priming studies further revealed that the more rapid B cell responses to H5 resulted from cross-reactive B cell immunity to the hemagglutinin H1 protein. Moreover, vaccination with the H1N1 vaccine virus was able to induce protective responses capable of limiting replication of the H5N1 vaccine virus to a level comparable with prior vaccination with the H5N1 vaccine virus without affecting H5N1 vaccine virus induced antibody response.</p></sec><sec><title>Conclusion</title><p>The findings indicate that previous vaccination with seasonal influenza vaccine may accelerate onset of immunity by an H5N1 <italic>ca</italic> vaccine and the heterosubtypic immunity may be beneficial for pandemic preparedness.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Taubenberger, Jk" uniqKey="Taubenberger J">JK Taubenberger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Scholtissek, C" uniqKey="Scholtissek C">C Scholtissek</name></author><author><name sortKey="Rohde, W" uniqKey="Rohde W">W Rohde</name></author><author><name sortKey="Von Hoyningen, V" 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sortKey="Bordi, L" uniqKey="Bordi L">L Bordi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hoffmann, E" uniqKey="Hoffmann E">E Hoffmann</name></author><author><name sortKey="Lipatov, As" uniqKey="Lipatov A">AS Lipatov</name></author><author><name sortKey="Webby, Rj" uniqKey="Webby R">RJ Webby</name></author><author><name sortKey="Govorkova, Ea" uniqKey="Govorkova E">EA Govorkova</name></author><author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Riel, D" uniqKey="Van Riel D">D van Riel</name></author><author><name sortKey="Munster, Vj" uniqKey="Munster V">VJ Munster</name></author><author><name sortKey="De Wit, E" uniqKey="De Wit E">E de Wit</name></author><author><name sortKey="Rimmelzwaan, Gf" uniqKey="Rimmelzwaan G">GF Rimmelzwaan</name></author><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA 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Ahmed</name></author><author><name sortKey="Oldstone, Mb" uniqKey="Oldstone M">MB Oldstone</name></author><author><name sortKey="Palese, P" uniqKey="Palese P">P Palese</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Scherle, Pa" uniqKey="Scherle P">PA Scherle</name></author><author><name sortKey="Gerhard, W" uniqKey="Gerhard W">W Gerhard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tumpey, Tm" uniqKey="Tumpey T">TM Tumpey</name></author><author><name sortKey="Renshaw, M" uniqKey="Renshaw M">M Renshaw</name></author><author><name sortKey="Clements, Jd" uniqKey="Clements J">JD Clements</name></author><author><name sortKey="Katz, Jm" uniqKey="Katz J">JM Katz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tamura, S" uniqKey="Tamura S">S Tamura</name></author><author><name sortKey="Tanimoto, T" uniqKey="Tanimoto T">T Tanimoto</name></author><author><name sortKey="Kurata, T" uniqKey="Kurata T">T Kurata</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li><li>Maryland</li></region></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Cheng, Xing" sort="Cheng, Xing" uniqKey="Cheng X" first="Xing" last="Cheng">Xing Cheng</name></region><name sortKey="Eisenbraun, Michael" sort="Eisenbraun, Michael" uniqKey="Eisenbraun M" first="Michael" last="Eisenbraun">Michael Eisenbraun</name><name sortKey="Jin, Hong" sort="Jin, Hong" uniqKey="Jin H" first="Hong" last="Jin">Hong Jin</name><name sortKey="Kemble, George" sort="Kemble, George" uniqKey="Kemble G" first="George" last="Kemble">George Kemble</name><name sortKey="Kulkarni, Deepali" sort="Kulkarni, Deepali" uniqKey="Kulkarni D" first="Deepali" last="Kulkarni">Deepali Kulkarni</name><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name><name sortKey="Xu, Qi" sort="Xu, Qi" uniqKey="Xu Q" first="Qi" last="Xu">Qi Xu</name><name sortKey="Zhou, Helen" sort="Zhou, Helen" uniqKey="Zhou H" first="Helen" last="Zhou">Helen Zhou</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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